Magnesium Stearate
Nanjing Muzhi Biotechnology Co., Ltd.
Email: xw79835@gmail.com
Phone: 025-58186679
Address: Room 204, Block C, Hatching Building, No. 99, Tuanjie Road, Jiangpu Street, Pukou District, Nanjing, Jiangsu Province
Magnesium stearate is hydrophobic and can block the dissolution of drugs from solid preparations; use it in the lowest dosage in the prescription. Impact on capsules: large dosage and prolonged mixing time can easily form a hydrophobic layer, making it difficult to disperse the contents after the capsule shell dissolves. Impact on tablets: the mixing coefficient of variation increases, and the tablet dissolution rate will decrease. Increased mixing time can reduce the tablet dissolution rate and crushing strength, and increase friability. The retardation effect of magnesium stearate causes a decrease in dissolution rate, which can be eliminated by adding a high-swelling disintegrant to the prescription. Due to its hydrophobicity, it can delay the dissolution rate of solid preparations, so it is required to use the lowest possible concentration and avoid using it with drugs that are incompatible with alkalinity, and pay attention to the difference in particle size between the raw material and magnesium stearate during use.
Nanjing Muzhi Biotechnology Co., Ltd.
Email: xw79835@gmail.com
Phone: 025-58186679
Address: Room 204, Block C, Hatching Building, No. 99, Tuanjie Road, Jiangpu Street, Pukou District, Nanjing, Jiangsu Province
Magnesium stearate is hydrophobic and can block the dissolution of drugs from solid preparations; use it in the lowest dosage in the prescription. Impact on capsules: large dosage and prolonged mixing time can easily form a hydrophobic layer, making it difficult to disperse the contents after the capsule shell dissolves. Impact on tablets: the mixing coefficient of variation increases, and the tablet dissolution rate will decrease. Increased mixing time can reduce the tablet dissolution rate and crushing strength, and increase friability. The retardation effect of magnesium stearate causes a decrease in dissolution rate, which can be eliminated by adding a high-swelling disintegrant to the prescription. Due to its hydrophobicity, it can delay the dissolution rate of solid preparations, so it is required to use the lowest possible concentration and avoid using it with drugs that are incompatible with alkalinity, and pay attention to the difference in particle size between the raw material and magnesium stearate during use.
